Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles.

نویسندگان

  • Lijun Wang
  • Yue Min
  • Doudou Xu
  • Fengjiao Yu
  • Wuzong Zhou
  • Alfred Cuschieri
چکیده

We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

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عنوان ژورنال:
  • Chemical communications

دوره 50 76  شماره 

صفحات  -

تاریخ انتشار 2014